Unknowns are things you don't have information on. Research is the way you can make the unknown to become known.
Uncertainties are things you don't know will happen. While additional research may help you discern the probability of something happening, no amount of research will allow you to know what will happen with certainty until it does.
So, when faced with unknowns, you can either choose to move forward in the face of the unknown, or do more research.
When faced with uncertainties, you can either choose to move forward in the face of uncertainty, or wait until the uncertainty plays out into certainty.
Treating an uncertainty like an unknown and trying to research your way to certainty will only result in wasted time and effort.